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Multicenter phase II study of weekly docetaxel, cisplatin, and S-1 (TPS) induction chemotherapy for locally advanced squamous cell cancer of the head and neck.

BMC Cancer · 2013 · PMC3599387 · PMID 23497365

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an increasing trendno p-value reported
In another way to modify 3 weekly TPF regimen there is an increasing trend for the substitution conventional 5-fluorouracil for oral prodrugs, including S-1 and capecitabine, in chemotherapy regimens.

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