The physiologically-based pharmacokinetic (PBPK) modeling approach has provided the basis for interspecies extrapolation, has focused on quantitative modeling of mass transport into and out of physiological compartments, and has made highly significant contributions to knowledge of systems and the fates of drugs [ 133 ].
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The mastermind approach to CNS drug therapy: translational prediction of human brain distribution, target site kinetics, and therapeutic effects.
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