Cytomegalovirus-induced salivary gland pathology: resistance to kinase inhibitors of the upregulated host cell EGFR/ERK pathway is associated with CMV-dependent stromal overexpression of IL-6 and fibronectin.

This “near rescue” of the mCMV-induced pathology of NB + 6 SMGs with GEF inhibition of EGFR phosphorylation is coincident with reduced mCMV infection compared to un-treated SMGs (compare Figure 2 G to F), as well as a highly significant (p<0.01) decline in downstream pERK protein expression (compare Figure 4 C to B; Figure 5 A).

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