Aldosterone increases early atherosclerosis and promotes plaque inflammation through a placental growth factor-dependent mechanism.

Aldo infusion for 4 weeks also resulted in signs of systemic inflammation, with increases in serum levels of the chemokine RANTES (regulated and normal T cell secreted; 1.6±0.1‐fold; Figure 3 B), a nonsignificant trend toward increased MCP1 levels (monocyte chemotactic protein‐1; 1.8±0.3‐fold, P =0.06), and a highly significant increase in spleen size (1.52±0.06‐fold increase in spleen weight/body weight; P <0.001; Figure 3 C).

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