Barely Significant
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From Pediatric Covariate Model to Semiphysiological Function for Maturation: Part II-Sensitivity to Physiological and Physicochemical Properties.

CPT Pharmacometrics Syst Pharmacol · 2012 · PMC3603432 · PMID 23887362

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an increasing trendno p-value reported
Increasing log P between 0.01 and 5.5 yielded a slight decreasing trend in the predicted clearance, whereas increasing the p K a between 2 and 12 yielded an increasing trend in predicted clearance.

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