Yeast-based automated high-throughput screens to identify anti-parasitic lead compounds.

Finally, compounds that were active against the parasite target, but had no significant effect on yeast expressing the equivalent human protein, were designated as ‘hits’ (see the electronic supplementary material, spreadsheet S1). For different screens against the same parasitic target, the overlap between the hits defined in this way is highly significant ( p ≪ 10 −14 ), demonstrating the reproducibility of our screening method.

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