Differential pre-mRNA splicing regulates Nnat isoforms in the hypothalamus after gastric bypass surgery in mice.

Importantly, certain bariatric procedures like gastric bypass surgery lead to potent changes in appetite and energy expenditure with highly significant and durable weight-loss [16] , [17] , [18] , most likely as a result of changes in gut hormones, such as ghrelin, peptide-YY (PYY) and glucagon-like peptide 1 (GLP1), as well as changes in neuronal and nutrient signals, that appear to override these intrinsic defects [8] .

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