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Frequent gain and loss of intronic splicing regulatory elements during the evolution of vertebrates.

Genome Biol Evol · 2012 · PMC3606033 · PMID 22619362

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an overall trendno p-value reported
The G/C content of the pentamers in these groups reveals an overall trend: pentamers that are frequent in all vertebrate flanks (group I) are highly A/U-rich while those that are abundant primarily in mammalian flanks (group III) are highly G/C-rich ( supplementary fig.

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