Trends in antiretroviral therapy and prevalence of HIV drug resistance mutations in Sweden 1997-2011.

PLoS One · 2013 · PMC3606434 · PMID 23533618

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closest p · 1.2× alpha

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boldest claim

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borderline significanceP = 0.06so close (0.05 < p ≤ 0.1)

Nonetheless, this continuous development of DRMs in patients starting ART since 2007 sets NNRTI apart from the other historical drug classes, where there is a decreasing trend; PI resistance for group IV in 2011 was significantly lower than expected (P = 0.04, chi-square test), and the same trend was seen for NRTI, although with borderline significance (P = 0.06, chi-square test).

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a decreasing trendno p-value reported

Several studies from the early years of 2000 showed an alarming prevalence of DRMs to the three main antiretroviral drug classes [2] – [4] , but more recently a decreasing trend has been reported from many countries [5] – [9] .

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.