Distinct roles for complement in glomerulonephritis and atherosclerosis revealed in mice with a combination of lupus and hyperlipidemia.

Although the difference in the ratio of C3:IgG deposition reached strong statistical significance when comparing Sle16.Ldlr −/− mice and Sle16 mice receiving the high-fat diet, it showed only a statistical trend ( P = 0.073) in mice receiving the low-fat diet, with a less steep gradient.

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