Prion pathogenesis and secondary lymphoid organs (SLO): tracking the SLO spread of prions to the brain.

Prion · 2012 · PMC3609058 · PMID 22895090

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34 , 97 While host age may represent an important barrier to the efficient transmission of peripherally acquired prion disease, data from these studies also suggest that there may be significant levels of subclinical prion disease in the elderly population. 34 , 97 Although many prion-exposed aged mice displayed histopathological signs of prion disease in their brains, prions were absent in the spleens of some mice.

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