Inhibition of PIKfyve by YM-201636 dysregulates autophagy and leads to apoptosis-independent neuronal cell death.

PLoS One · 2013 · PMC3609765 · PMID 23544129

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However, there was a highly significant decrease in the number of electron-dense lysosomes detected (3.33±0.38/cell profile in DMSO-treated cells vs. 0.60±0.21/cell profile in YM-201636-treated cells, n = 4 independent experiments, 6–12 cell profiles/experiment, p<0.001).

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