Transcriptomic analysis of Streptomyces coelicolor differentiation in solid sporulating cultures: first compartmentalized and second multinucleated mycelia have different and distinctive transcriptomes.

With the aim of focusing on the most reliable data possible, we followed a very conservative strategy, selecting only genes with highly significant abundance values ( p -values<0.05) for all the comparisons (MII 24 h /MI 16 h , MII 48 h /MI 16 h , MII 72 h /MI 16 h ), and discarding genes with p -values>0.05 in at least in one of the comparisons analyzed (see Methods for details).

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