highly significantP = 1.6×10 −13
Although there was no transcriptome-wide correlation between ZC3H11 binding and the RNAi effect (Supplementary Table S1 , sheet 5), every single one of the ZC3H11-bound heat-shock chaperone mRNAs was decreased in the RNAi cells ( Table 1 ): the enrichment of chaperones in the subset that was both ZC3H11-bound and reduced in heat-shock was highly significant (P = 1.6×10 −13 ) (Supplementary Table S1 , sheet 7).