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3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing.

BMC Cancer · 2013 · PMC3617005 · PMID 23446043

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more or less significantno p-value reported
3D culture of pancreatic tumour cells from KRAS mouse model Having gone through numerous passages, established cancer cell lines bear the risk of differing to a more or less significant extent from their original parent cell line.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.