Genetic and genomic architecture of the evolution of resistance to antifungal drug combinations.

PLoS Genet · 2013 · PMC3617151 · PMID 23593013

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may be significantno p-value reported

Despite the emergence of target-based resistance to calcineurin inhibitors in vitro , there may be significant constraints that minimize the emergence of resistance in the human host.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.