Population-based input function modeling for [(18)F]FMPEP-d 2, an inverse agonist radioligand for cannabinoid CB1 receptors: validation in clinical studies.

Because of this bias, PBIF modeling found a larger decrease in V T in cannabis smokers (−27% in the prefrontal cortex compared with −19% using full input), and the group×region interaction was statistically highly significant (F = 17.1, p = 0.00000001) ( Fig. 2B ).

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