First, ChIP-seq was performed using specific antibodies against PML and RARα respectively, and a total of 3,551 highly significant (FDR < 0.01) PML/RARα binding sites were identified (Additional file 7 : Table S3).
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Structurally differentiated cis-elements that interact with PU.1 are functionally distinguishable in acute promyelocytic leukemia.
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