The same trend was found in HeLa cells but failed to reach significance (Figure 5 H) because the NL-AN and NL-CP chimeras reduced the surface expression of both receptors (Figures 2 D and 5 C).
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The transmembrane domain of HIV-1 Vpu is sufficient to confer anti-tetherin activity to SIVcpz and SIVgor Vpu proteins: cytoplasmic determinants of Vpu function.
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