Pathology and pathogenesis of vascular cognitive impairment-a critical update.

Macroscopic studies in VaD revealed mean volumes of infarcted brain loss of 39–47 ml (range 1–229 ml) (Zekry et al., 2003a ), while others suggested that dementia is not consistently related to the volume of infarction (del Ser et al., 1990 ) or found only a nonsignificant trend for lobar infarcts to occupy more brain volume than in patients without dementia (Vinters et al., 2000 ).

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