Barely Significant
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FNDC5/irisin is not only a myokine but also an adipokine.

PLoS One · 2013 · PMC3623960 · PMID 23593248

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a decreasing trendno p-value reported
However, this expression shows a decreasing trend after 3 weeks of endurance exercise ( Figure 4A ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.