21 In this latter study, the correlation between CSF BH 4 concentration before treatment and social interaction improvement was only borderline significant. 21 Fernell et al. 22 used positron emission tomography to examine dopamine metabolism changes with BH 4 treatment; a decrease in the baseline elevation in D 2 receptor binding occurred with BH 4 treatment but this change was not correlated with treatment response.
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Metabolic effects of sapropterin treatment in autism spectrum disorder: a preliminary study.
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