STAT3 activity is necessary and sufficient for the development of immune-mediated myocarditis in mice and promotes progression to dilated cardiomyopathy.

EMBO Mol Med · 2013 · PMC3628107 · PMID 23460527

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Accordingly IL-17, already displaying an increasing trend at the mRNA level in the heart (Supporting Information Fig S2), was detected by IF in the hearts of Stat3 C/C mice from 3 weeks of age ( Fig 5E ), correlating with the appearance of CD4 + cells and increasing with disease progression.

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