An increasing trend in BACE1 mRNA levels was observed in cells treated with H 2 O 2 , but this was not statistically significant when normalised to either actin or β2-macroglobulin mRNA ( Figure 2D ).
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Mild oxidative stress induces redistribution of BACE1 in non-apoptotic conditions and promotes the amyloidogenic processing of Alzheimer's disease amyloid precursor protein.
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