DNA-bound platinum is the major determinant of cisplatin sensitivity in head and neck squamous carcinoma cells.

Remarkably, there was a highly significant correlation (Spearman’s rho = 0.95, p<0.001) between BRCA1 and BRCA2 expression in the 19 cell lines ( Table 1 ), suggesting that these genes are co-regulated in HNSCC, similar to what has been shown in mammary epithelial cells [35] .

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