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The development and application of the two real-time RT-PCR assays to detect the pathogen of HFMD.

PLoS One · 2013 · PMC3630163 · PMID 23637836

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an increasing trendno p-value reported
Epidemiological data show that HFMD had an increasing trend in Southeast Asia in the past 20 years.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.