Obstructive sleep apnea syndrome: natural history, diagnosis, and emerging treatment options.

192 Recent findings from the Sleep Heart Health Study also demonstrated a significant longitudinal relationship between OSA and the development of hypertension among individuals who were normotensive at baseline examination; however, these relationships were attenuated to borderline significance after taking into account obesity 193 There are several factors that may account for the difference between the results of the Wisconsin Cohort Study and the Sleep Heart Health Study, including the different definitions used in the assessment of the AHI as a marker of OSA, differences in the ascertainment of blood pressure measurement (ie, measuring blood pressure at home vs clinic), and using different cutpoints in defining hypertension (140/90 vs 135/85).

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