Expression of tryptophan 2,3-dioxygenase and production of kynurenine pathway metabolites in triple transgenic mice and human Alzheimer's disease brain.

However, a decreasing trend of neuroprotective, PIC concentration level in the hippocampus and cerebellum of older adult AD mice was observed when compared to WT counterpart ( Fig. 6E ). mRNA expression of downstream metabolic enzymes of the KP We also measured the mRNA expression of three downstream metabolic enzymes of KP involved in QUIN and PIC production and/or catabolism: 3-hydroxyanthranilic acid oxidase (3HAAO), α-amino-α-carboxymuconate-semialdehyde decarboxylase (ACMSD), and quinolinate phosphoribosyltransferase (QPRT) in 3xTg AD mouse brains at various ages ( Fig. 7 ).

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In addition, we also found an increasing trend of QUIN production with age in both AD and WT mice where this increase was more profound in the AD mice group.

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