TOM40 mediates mitochondrial dysfunction induced by α-synuclein accumulation in Parkinson's disease.

PLoS One · 2013 · PMC3633917 · PMID 23626796

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Although it is unclear how α-Syn could promote the reduction in TOM40 levels, we found a highly significant negative correlation between α-Syn and TOM40 by performing data mining on expression levels derived from 381 human blood samples (data not shown) suggesting that α-Syn is a negative regulator of TOM40 either directly or by indirect mechanisms.

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