One explanation might be the mild but highly significant 1.5-fold increase in liver iron measured in these heterozygote mice (85 ±13 μg/g wet tissue in WT mice n = 11, vs 132 ±22 μg/g wet tissue in Hepc+/− mice, n = 11, p = 2.8E-05).
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Role of hepcidin in the setting of hypoferremia during acute inflammation.
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