Impact of vitamin D on chronic kidney diseases in non-dialysis patients: a meta-analysis of randomized controlled trials.

Given the fact that vitamin D is generally deficient and metabolically disordered in patients with CKD [8] , [9] , supplementation of vitamin D may be significant throughout CKD evolution, especially at early and moderate stages.

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Of the limited clinical studies that have explored extra-skeletal benefits of vitamin D, the VITAL trial (selective vitamin D receptor activation with paricalcitol for the reduction of albuminuria), a well-designed and relatively large-scale study, has shown promising but borderline significant results concerning albuminuria improvement [6] .

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