miR-221 affects multiple cancer pathways by modulating the level of hundreds messenger RNAs.

Front Genet · 2013 · PMC3635019 · PMID 23630541

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hedged sentence

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closest p · 0.0× alpha

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boldest claim

The sentences

highly significantp −value =1 × 10 −15actually significant

A highly significant ( p −value =1 × 10 −15 ) enrichment for miR-221 target sequences was detected in the 3′UTRs of many of the down-regulated genes (Figure 1 ).

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