Distinct types of disorder in the human proteome: functional implications for alternative splicing.

Since the A and flanking C1 and C2 exons constitute only a small portion of the coding genome (∼10 million nucleotides as per our dataset), this enrichment is highly significant as revealed by a Chi-square test (P<1.99e-108), when comparing the ratios of driver vs. passenger mutations in alternative splicing neighborhoods as compared to the rest of the exome.

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