Structural mimicry between SLA/LP and Rickettsia surface antigens as a driver of autoimmune hepatitis: insights from an in silico study.

Theor Biol Med Model · 2013 · PMC3636016 · PMID 23575112

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highly significantno p-value reported

The obtained results suggest that a highly significant, local sequence similarity between SLA/LP and a non-homologous bacterial protein from Rickettsia spp. might drive autoimmunity to SLA/LP, through initial CD4 + T cell recognition and subsequent humoral response.

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