Nonresponse to interferon-α based treatment for chronic hepatitis C infection is associated with increased hazard of cirrhosis.

PLoS One · 2013 · PMC3636226 · PMID 23637856

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marginally significantno p-value reported

In univariate proportional hazards models, stratified by baseline fibrosis stage, patients achieving SVR had a marginally significant reduction in death compared to never treated patients (HR = 0.24, CI 0.05–1.06, Table S4 ).

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fell just short of statistical significanceno p-value reported

In univariate proportional hazards models stratified by baseline liver fibrosis stage (0–1 and 2–3), UCSF treatment nonresponders showed an increased hazard for developing cirrhosis when compared to the never treated group, but this result fell just short of statistical significance (HR = 2.28, CI 0.93–5.59, Table S3 ).

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did not achieve significanceno p-value reported

The hazard ratio for treatment relapsers also tended toward protection, but did not achieve significance.

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