A randomized cross-over study of inhalation of diesel exhaust, hematological indices, and endothelial markers in humans.

Similar increase was seen for hemoglobin concentration with borderline significance [ Mean DE effect was 0.2 gm/dL (95% CI: -0.01 to 0.4 gm/dL; p=0.06 for hemoglobin)], but not erythrocyte count.

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Effects of diesel exhaust on endothelial adhesion molecules and inflammatory cytokines: results from the multiplex cytokine assay Using the multiplex assay, we found that the endothelial cell adhesion molecules E- selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) showed a small trend toward increase in the plasma following DE exposure when compared to FA exposure at 22 hours, but variability in measurements was very high and no significant findings were detected (Table 3 ).

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Using the multiplex assay, small borderline significant increases in matrix metalloproteinase-9, interleukins (IL)-1beta, 6 and 10 occurred 7 hrs post exposure initiation, whereas E-selectin, intercellular adhesion molecule-1, and vascular cell adhesion molecule -1, and myeloperoxidase 22 hrs post exposure.

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