an overall trendp=2.74×10 -7
A formal test for trend using ordinal measures (derived from quartile cut-points) supported an overall trend for increasing creatinine (HR: 1.42; 95% CI: 1.26–1.60; p=2.74×10 -7 ) and UACR (HR: 1.55; 1.37–1.74; p=1.18×10 -12 ) and decreasing serum albumin (HR: 0.82; 95% CI: 0.73–0.92; p=0.0005) and eGFR (HR: 0.71; 0.63–0.81; p=1.07×10 -7 ) to be associated with risk for all-cause mortality.