The progestin-only contraceptive medroxyprogesterone acetate, but not norethisterone acetate, enhances HIV-1 Vpr-mediated apoptosis in human CD4+ T cells through the glucocorticoid receptor.

PLoS One · 2013 · PMC3643923 · PMID 23658782

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highly significantno p-value reported

However, the high affinity of MPA for the GR and the known effects of the GR on immune function suggest that effects of DMPA on both systemic and local immunity via the GR may be highly significant.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.