The effect of HPV status remained highly significant when palliative patients were excluded; OS at 3 and 5-years in radically treated HPV-positive patients was 82.6% and 75.4%, compared to 39.6% (95% CI: 32.5-46.7) and 31.1% (95% CI: 24.4-37.6) in HPV-negative patients, corresponding to a 74% reduction in the death rate (HR 0.259, 95% CI 0.152-0.440, p < 0.001).
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Human Papillomavirus-associated oropharyngeal cancer: an observational study of diagnosis, prevalence and prognosis in a UK population.
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