MPN patients harbor recurrent truncating mutations in transcription factor NF-E2.

J Exp Med · 2013 · PMC3646501 · PMID 23589569

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highly significantno p-value reported

In contrast, NF-E2 mutant-bearing mice contain an expansion of all three progenitor types, CMP, MEP, and GMP, and show a highly significant increase in the number of KL cells, CMP, and GMP over WT NF-E2–expressing mice ( Fig. 6, F–I ).

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