The biodiversity hypothesis and allergic disease: world allergy organization position statement.

World Allergy Organ J · 2013 · PMC3646540 · PMID 23663440

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highly significantno p-value reported

In the case of asthma, the EU GABRIEL collaboration reported highly significant genome-wide associations with loci on chromosomes-17 ( ORMDL3/GSDMB), - 2 ( IL1RL1/IL18R, -6 ( HLA-DQ gene cluster), -9 ( IL33), - 15 ( SMAD3) and -22 ( IL2RB ) that is claimed to account for up to 50% of asthma risk across the life course [ 109 ].

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