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Application of the central composite design to optimize the preparation of novel micelles of harmine.

Int J Nanomedicine · 2013 · PMC3652517 · PMID 23674893

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an increasing trendno p-value reported
Zeta potential showed the same trend with DL, whereas particle size exhibited an increasing trend.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.