Barely Significant
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Multipurpose contrast enhancement on epiphyseal plates and ossification centers for bone age assessment.

Biomed Eng Online · 2013 · PMC3652796 · PMID 23565999

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might not be significantno p-value reported
However, we suggest that this logic can be further improved by introducing the ‘optimum’ value, since if there is no structural change, the enhanced contrast might not be significant enough to distinguish features in the ossification sites.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.