Although not essential for the action of ACh alone, the role of CaMKII as well as AMPK and CaMKK may be significant under the potentiating action of ANP, and perhaps even more so in response to CCK and BK with their modulatory effects on PFL(3) via Ca 2+ -influx pathways.
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Acetylcholine promotes Ca2+ and NO-oscillations in adipocytes implicating Ca2+→NO→cGMP→cADP-ribose→Ca2+ positive feedback loop--modulatory effects of norepinephrine and atrial natriuretic peptide.
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