Analysis of loss of heterozygsity effect on thyroid tumor with oxyphilia cell locus in familial non medullary thyroid carcinoma in Iranian families.

It is possible that the nature of the tumor-initiating oncogenic event may be significant in determining the genomic stability of the tumor and this may have implications for tumor behavior and prognosis or somatic inactivation of the putative susceptibility gene, located at 19p13.2, has occurred through the other mechanisms, such as microdeletions, point mutation, or promoter hyper-methylation and interact with this region.

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