Early-life and contemporaneous nutritional and environmental predictors of antibody response to vaccination in young Gambian adults.

For serotype 14, no associations were observed with birth weight or low birth weight, but a trend towards significance was observed for infant growth from birth to three months of age (negative trend), infant weight at 12 months of age (negative trend) and season of birth (higher in hungry season births).

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No significant associations were observed, with the exception of a marginally significant relationship between rate of growth between six and twelve months of age and antibody response to serotype 14, when adjusted for pre-vaccination antibody levels ( β = −0.116, p = 0.043; other data not presented). 4.

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With the exception of antibody response to serotype 23F of the pneumococcal vaccine, a highly significant effect of pre-vaccination antibody levels on post-vaccination titres was observed for both vaccines.

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