Piperine could significantly enhance the oral bioavailability of carbamazepine, phenytoin, and pentobarbitone possibly by decreasing the elimination and/or by increasing its absorption.[ 21 – 23 ] A highly significant increase in the systemic availability and AUC of propranolol was observed when administered along with piperine, while its elimination kinetics was not changed.
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Bioenhancers from mother nature and their applicability in modern medicine.
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