Moreover, there was a borderline significant interaction between the individual or combined MDM2 genotypes of the two polymorphisms and HPV16 L1 seropositivity on risk of OSCC ( P (int) = 0.060 for MDM2 SNP309, P (int) = 0.009 for MDM2 SNP2164, and P (int) = 0.005 for the combined MDM2 genotypes).
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