Barely Significant
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Mechanisms underlying restoration of hepatic insulin sensitivity with CB1 antagonism in the obese dog model.

Adipocyte · 2013 · PMC3661137 · PMID 23700552

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highly significantno p-value reported
Our study also revealed a highly significant increase in plasma adiponectin in the RIM treated animals that occurred in concert with the improvement in insulin sensitivity as well as a marked increase in the expression of liver adiponectin receptors (ADR1 and ADR2).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.