highly significantp = 0.0008
While rs2555639 was the only SNP that was significantly associated with risk of colon cancer in each of the discovery and validation sets independently, several additional SNPs had highly significant association with risk when combining data from the discovery and validation samples ( Table 5 ), including rs1365611 (OR = 1.73, 95%CI:1.26–2.37, p = 0.0008), rs6844282 (OR = 1.42, 95%CI:1.10–1.83, p = 0.0078), and rs2332897 (OR = 1.74, 95%CI:1.27–2.38, p = 0.0006).